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cialis (tadalafil)

Pharmaceutical medicine Cialis: peculiarities, mechanism of action and dose

cialis (tadalafil)

Main action of Cialis

Tadalafil is the active component of this medicine. The medicine action is directed to the slowing down the enzyme cGMP. Generation of nitric oxide is reached at the stimulation of penis, and this in its turn causes inhibition of the enzyme PDE5 and a sharp increase of cGMP content in the penis cells. These factors provide the main effect of the drug Cialis and namely the relaxation of the musculature of the corpus cavernosum, blood flow and the improvement of erection for prolonged sexual intercourse. Such effect cannot be reached without sexual stimulation of a men. Cialis is not aphrodisiac and does not affect the vitality of sexual desire.

The active component of Cialis does not inhibit other types of enzymes, and therefore does not have a significant impact on human. Its admission does not affect the functions of the heart and circulatory system, does not affect the level of filtering of liver, and does not affect the relaxation or spasm of transverse muscles. Clinical research allows speaking about a neutral impact on sperm quantity and life cycle of sperm. Cialis has no effect on hormones: this includes all types of hormones. The main effect of medication begins after 15 minutes of oral consumption. It may last more than 1.5 days.

The active ingredient of the medicine gets in the blood through the digestive system. Studies have shown that the concentration of active substance in blood plasma reaches its maximum in 120 minutes after Cialis intake. Food and water in the stomach does not influence the speed of action of the active ingredient and its duration. The active substance is bound in the organism and is excreted after 17 hours. Kidneys and digestive system participate in the excretion.

Which cases is this medicine prescribed in?

Aggravation of erection, problems with its quality and the duration of sexual intercourse.

Medicine intake

The medicine is produced in the form of firm-coated tablets. Tablets are taken orally with lots of plain water. There is no need in the chewing or dissolving of the tablet in a mouth. These actions do not influence the speed of the action of active ingredient. The patient should plan his sexual intercourse and take into account the time period of 20 minutes because the action of Tadalafil starts after this period of time after administration. Daily dose is 1 tablet.

Negative action of the medicine for an organism

The clinical research showed the perfect tolerance by all groups of persons. But some adverse effects were registered. They are as follows:

  • headache
  • diarrhea (short-term liquid stool)
  • pain in back and lumbar spine
  • hyperemia of upperparts
  • stuffiness in nose
  • weakness, sometimes myalgia of upper and lower extremities
  • pain in eyes
  • redness of the eyeball mucous membrane
  • profuse lacrimation
  • allergic reaction

Pay attention: in the clinical practice the cases of prolonged erection were registered. If the patient has the erection more than 4 hours he should seek medical assistance. The prolonged erection negatively affects the nutrition of the tissues of the penis and this may lead to serious consequences.

Contraindications

This drug is developed for men and therefore it is not prescribed to women. It is contraindicated the prescription of Cialis for children less than 18 years of age. If a patient has individual intolerance to the medicine or its components, he should immediately stop the administration. It is contraindicated to prescribe Cialis to patients who use in their treatment the agents from the group of nitrates.

Cardiovascular diseases are complex conditions and therefore doctors often prohibit patients with this diagnosis sexual contact. The patients who recently suffered myocardial infarction (particularly transmural, with considerable damage of cardiac walls) should not take Cialis. Also the patients with established heart failure of 2 degree and unstable angina should not administrate the medicine. The direct contraindication for Cialis administration is the presence in history of arrhythmia and arrhythmia. It is prescribed with caution at the increased or decreased blood pressure. The same applies to systemic blood diseases, benign and malignant tumors, leukemia and anemia. It is contraindicated to take the medicine to persons with congenital or acquired curvature of the penis, and sclerosing processes in the corpora cavernosa. Chronic renal failure is an indication for additional examination of the patient. And only then Cialis may be prescribed. It is forbidden to combine the treatment with antiarrhythmic and Cialis taking, especially with beta blockers.

Combination with other medicines

The combined intake of Cialis and nitrates leads to lower blood pressure. The combination of inhibitors of CYP3 A4 and Cialis increases its concentration in blood plasma. It is contraindicated the intake of Cialis and corticosteroids, erythromycin. Please note: antacids and medicines obducing mucous coat of stomach are used in the treatment of gastritis and gastric ulcer. They can reduce the absorption rate of the active ingredient of Cialis and its level of concentration in the blood. It is desirable to exclude the combination of antihypertensive drugs and Cialis.

Overdose

Exceeding the permissible dosage of the medicine increases the chance of negative effects. There is no direct antidote to Tadalafil. The symptomatic therapy is prescribed in the case of detection of side effects or in case of excess dosage.

Storage conditions

The medicine should be kept in a dry place. Keep out reach of children. The storage temperature is 15 – 25C.