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viagra (sildenafil)

Viagra is the powerful stimulator of erection

viagra (sildenafil)

Viagra is the powerful stimulator of erection

All people know this name and this is not simply clever publicity trick. The preparation, developed just few decades ago, has become a real solution for men with problems of impotence. In fact, what is erectile dysfunction? It is the pathology of physiological or psychogenic (often mixed) type, which does not give a sufficient amount of blood to fill cavernous body of penis during sexual stimulation. Even after eliminating the psychological causes of the problem, the chemical reaction remains, isozyme just suppresses the substances generating during erection, preventing the blood inflow in the penis.

The solution is simple – to block the enzyme, PDE5, phosphodiesterase. But the same enzyme, only with other numeric value, is present in other tissues of the body and the medication should have a very narrow range of action in order not to provoke a heart attack or other adverse effects. So sildenafil was developed.

Its pharmacological action directed on strengthening of nitric oxide effect, which is released to cavernous body during stimulation. The nitric oxide causes increase of the level of cGMP, relaxation of smooth muscles of the penis and filling vessels with blood. When there are some disorders this process is interrupted and erection is not happened. Sildenafil blocks the action of PDE5, which fermented cGMP– this allows blood to circulate freely. It should be mentioned that Viagra is several thousand times more active against PDE-5 than, for example, to the enzyme PDE-3, which plays a key role in controlling of myocardium muscle contraction. So, at Viagra taking there is no risk that the active ingredient will negatively affect other isoenzymes involved in the vital processes. In addition, the effect of sildenafil is reversible – all functions are restored after the period of action of the drug. That is why Viagra does not cure erectile dysfunction, but is a means of symptomatic therapy.

Combination Viagra and other preparations

There are drugs that influence the absorption and action of sildenafil. The attending doctor should know about all medicines that a patient takes regularly or from time to time. For example, for men administrating nitroglycerin or other drugs containing organic nitrates and nitrites, sildenafil is strictly prohibited – this may lead even to a lethal outcome, as the combined action of both medicines cause sudden hypotensive effect. It is necessary the consultation with an urologist before starting administration of Viagra, even if the drug is OTC. Viagra is not a magic pill for erection that is suitable for everybody. This is the same drug as many others. What drugs can affect the health of the patient, if taken with sildenafil?

  • alpha-blockers. This drugs are to treat diseases of the prostate and hypertension. They cause sharp decrease in AD in combination with Viagra and, consequently, weakness, nausea, dizziness.
  • protease inhibitors. In this case it is necessary to adjust the dose of sildenafil to a minimum.
  • any tablets and injections, implants for erection improvement. Their compatibility is not enough investigated and doctors recommend not to combine similar drugs.

Right dosage

Usually Viagra is available in tablets of 50 and 100 mg. If the recommended dose did not give the result, you should consult your doctor. But to exceed maximum dose of 100 mg once a day is prohibited.

The lowest dose of 25 mg is prescribed to people over 65, to patients with compromised history – chronic severe renal and/or hepatic failure.

Tablets administration

It is not recommended to administrate Viagra after meal, especially fat, – the drug effect will start later. The most successful variant is to take Viagra after few hours after eating, 40-60 minutes before sexual intercourse. Viagra should not be combined with alcohol, because it can cause full absence of the effect and also to affect health.

Viagra side effects

As a rule, all the negative effects of the drug are mild or moderate and pass fully in several hours. Often the overdose provokes these side effects. Most often (from 1 to 10% of cases), patients suffer from headache, rush of blood to the face, stomach pain. Vision disorders occur less than 1%: opacity, color mixing, increased heart rate, swelling of the nose, dyspepsia. There are also reports of hypotension, rash, bleeding from the nose. The number of these cases is less than 0, 01%.

Any of the above symptoms is a signal for call to the doctor. The drug should not be administrated.

Special remarks on the drug administration

The self treatment is unacceptable despite the fact that manufacturers emphasize the safety of Viagra; in any case the consultation of urologist is needed. First, sildenafil is not a drug for erectile dysfunction treatment and its constant administration does not guarantee a stable result for a long period of time. Its aim is to provide the man the opportunity to lead a sex life of full value, i.e. symptomatic. Secondly, the doctor should identify the causes of erectile dysfunction and to prescribe therapy, in the complex of which it is admissible to use Viagra.

It is prescribed with caution to persons who have diseases predisposing to priapism. In addition, the anatomical curvature of the penis is also the contraindication for the use of Viagra because the drug can cause injury to penis tissues. The drug is also not prescribed to persons with cardiovascular diseases, whom sexual activity is temporarily prohibited. , Sildenafil may be taken after ischemic stroke or myocardial infarction recovery period at least six months in the absence of risk of complications. In addition, the physician should evaluate the risk of blood pressure decrease while taking the drug, Viagra is undesirable at severe disorders of blood pressure regulation.